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Second-line treatments for men who do not respond adequately to oral medications include: Intracavernosal injections (alprostadil, combination therapies): These medications are injected directly into the penis before sexual activity, producing erections in 70-80% of users
Nutr Rev
This multi-stage barrier means oral doses require significantly higher amounts to achieve comparable blood levelsa key reason why oral formulations are typically dosed higher and absorbed unpredictably based on individual GI function
The resulting flavonoid metabolites are then disseminated across various tissues, including the cardiovascular system and central nervous system, where they may interact with molecular targets
