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The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]

For instance, in the STEP 2 trial, nausea from semaglutide rose from 5% at week 1 to 15% by week 13, then decreased to 8% by week 68

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When the immune system releases histamine in your tissues, you may experience allergy symptoms, such as itchy eyes, skin rashes, inflammation, or in extreme cases, life-threatening anaphylaxis