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In the absence of a known mechanism for this association, we urge clinicians to weigh the concern for an increased risk of a rare but potentially blinding eye condition with the many therapeutic benefits of semaglutide. 1 A commentary also published yesterday was written by coauthors of the July 2024 JAMA Ophthalmology study with the higher risk estimates
The case of levodopa degradation in PD is illustrative: scientists identified a gut bacterial tyrosine decarboxylase that was eating up patients Parkinsons medication, and they found a small-molecule inhibitor that could block this enzyme and thus prevent levodopa loss
Low risk of hypoglycaemia One of the most reassuring findings from clinical trials is the low risk of hypoglycaemia when Mounjaro is combined with metformin
Factors That Influence the Right Maintenance Dose Several factors affect what tirzepatide maintenance looks like after weight loss: Appetite response: How quickly hunger returns when doses change Side-effect tolerance: Lower doses are often better tolerated long term Weight-loss history: Repeated regain may require ongoing support Daily habits: Nutrition, movement, and sleep consistency matter Maintenance works best when dosing decisions are personalized rather than standardized
2021 Jan 7;16(1):1
