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For example, (1) Glucagon-like peptide 1 (GLP1) is an intestinal hormone that can enhance insulin secretion in a glucose-dependent manner by activating the GLP-1 receptor (GLP-1R) that is highly expressed on islet cells

Potential mechanisms for this include a natriuretic effect as well as a direct vasorelaxant effect on the vascular system of GLP-1

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Semaglutide and Tirzepatide are both GLP-1 receptor agonists, with Tirzepatide having additional action on and a higher affinity for glucose-dependent insulinotropic polypeptide (GIP) receptors