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Diabetes Res Clin Pract (2012) 98(2):27184

Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)

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Creatinine levels may decline alongside reductions in muscle mass, which can complicate kidney marker interpretation over time