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Osteoarthritis: By promoting cartilage metabolism and reducing inflammatory cytokines, peptides offer a regenerative alternative to repeated corticosteroid injections that can accelerate cartilage degradation

The recent advancement in tissue engineering and regenerative medicine (TERM) has shed light on the application of peptide modification, which potentially results in enhanced medication delivery, reduced harm to healthy tissues, and enhanced cell targeting

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local anesthetic applied Injection Points: Typically include the AC joint capsule and coracoclavicular ligament attachments Solution Used: 15-25% dextrose + 1% lidocaine or procaine Guidance: Can be done freehand or under ultrasound guidance for precision Post-Injection Care Mild soreness or swelling is expected for 13 days Avoid anti-inflammatory medications (they may blunt the desired response) Gentle range of motion exercises encouraged Physical therapy may be added at any time Treatment Frequency Prolotherapy is typically performed every 34 weeks 36 sessions are usually recommended depending on severity and how you are progressing Clinical Evidence Supporting Prolotherapy for AC Joint Injury While large randomized controlled trials are limited for AC separation specifically, prolotherapy has demonstrated efficacy in multiple musculoskeletal conditions involving ligament and joint instability: Rabago et al