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Kubota, M., Yamamoto, K

Eating smaller meals and avoiding greasy foods can also help

Develop., 18, 551557, 2006

Bring your symptom diary if you have kept one, and be ready to describe: When symptoms began in relation to starting or increasing the dose How often you are experiencing bowel changes and what they look like Whether symptoms are improving, worsening, or staying the same What you have already tried to manage them and whether it helped How much the symptoms are affecting your daily life and wellbeing Your prescriber may consider adjusting your dose-escalation schedule, recommending specific dietary changes, or referring you to a gastroenterologist if symptoms are complex or persistent

This depletion causes NAPQI to covalently bind to macromolecules, particularly proteins, which subsequently leads to malfunction of the mitochondria