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Retatrutide produces more gastrointestinal distress but also delivers more weight loss as a monotherapy

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The broader pattern of GLP-1 drugs reducing addictive and compulsive behavior has shown up across multiple datasets, including a 606,000-veteran cohort published in BMJ earlier this year showing meaningful reductions in alcohol, nicotine, and opioid use disorder rates in GLP-1 users

It helps patients understand their treatment choices

The peptide chains unfold and aggregate, rendering the medication less effective at binding to GLP-1 receptors and triggering the appetite-suppressing cascade your body relies on for weight management