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Tirzepatide produced up to about 20.9 percent average weight loss at its studied doses over 72 weeks, per the SURMOUNT-1 trial in the New England Journal of Medicine, 2022, and federal health guidance describes obesity as a chronic disease where medication is often continued long term, as outlined by the National Institute of Diabetes and Digestive and Kidney Diseases

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These individuals are not currently eligible for GLP-1 coverage based solely on weight

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Glucagon-like peptide 2 (GLP-2) stimulates postprandial chylomicron production and postabsorptive release of intestinal triglyceride storage pools via induction of nitric oxide signaling in male hamsters and mice