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It does so by also potentiating FSH actions on granulosa cells, and it was demonstrated that the IGFR was absolutely required for FSH-mediated activation of the PI3K/Akt pathway which is a pro-survival cascade, and subsequent granulosa cell differentiation (59, 60)
Therefore, parenteral cyanocobalamin should be administered to a pregnant woman if the benefits outweigh the risks (10, 11)
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