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On the Alzheimers side, amyloid PET and plasma p-tau217 now do real work at the front door of trials, confirming that enrolled participants actually carry the pathology in question, as the amyloid-confirmed EVOKE cohorts illustrate

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[18] [19] Symptoms include sudden pain in the upper right abdomen, fever, yellowing of the skin or eyes (jaundice), pale stools, or dark urine