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That is a substantial monotherapy effect for an appetite-axis-only agent, and it established cagrilintide as a credible weight-management candidate on its own

2,3 REDEFINE 1 was a 68-week, double-blind, randomized, placebo- and active-controlled phase 3 trial that evaluated the efficacy and safety of once-weekly CagriSema versus cagrilintide 2.4 mg monotherapy, semaglutide 2.4 mg monotherapy, and placebo, all in combination with lifestyle intervention in 3,417 adults with obesity or overweight with one or more obesity-related complications and without type 2 diabetes

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L-lysine helps in the creation of carnitine which converts fatty acids into energy aiding in weight loss