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Due to the promotive effect of GLP-1R agonism on -cells proliferation and survival, concerns of tumorigenesis, especially pancreatic cancers, have been raised about incretin-based therapies (89)

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Your three non-negotiables for muscle preservation: High protein intake 1.6-2.2 g/kg body weight daily, every single day Consistent resistance training 2-4 sessions weekly with progressive overload Reasonable weight loss pace 0.5-1% body weight per week maximum Do these three things consistently, and you'll preserve the vast majority of your muscle mass while losing fat

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Genetic recombinant experiments were reviewed by Safety Officer in RIKEN, and approved by the director of RIKEN Wako Campus (approval number: 2022-029(1))