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In the UKPDS (the United Kingdom Prospective Diabetes Study), intensive care in T2DM patients reduced HbA1c from 7.9% to 7.0%, with a 25% risk reduction in microvascular outcomes, although with no reduction in the risk of kidney outcomes specifically [37]
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GLP-1 medications are most effective as part of a broader lifestyle change
Also, during space missions, astronauts are exposed to a complex combination of stressors, including microgravity, cosmic radiation, psychological stress, isolation, and nutritional changes
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