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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
The Research: What Studies Have Found Important compliance note: The following section describes research findings from published studies
The compound is available in two primary forms, with oral capsules focusing on gastrointestinal applications and injectable formulations used for more systemic effects
Importantly, triggering this cascade either via BDNF depletion or C/EBP activation could accelerate A and tau pathology in 3 Tg mice, suggesting that BDNF/TrkB reduction and C/EBP activation may work cooperatively to drive AD pathogenesis
& Kim, K
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