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Whilst many symptoms improve with appropriate B12 treatment, not all resolve completely, especially if neurological damage was severe or prolonged before treatment commenced

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Unlike previously tested LRRK2 kinase inhibitors with significant side effects, Vit B12, derivative AdoCobalamin (AdoCb) specifically, exhibits a neuroprotective effect by regulating the activity of LRRK2 kinase (Schaffner et al

J Park Dis 11:949970 Martin A, Youdim K, Szprengiel A, Shukitt-Hale B, Joseph J (2002) Roles of vitamins E and C on neurodegenerative diseases and cognitive performance