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Research has documented GHRH-Ipamorelin synergistic GH release , characterising combined responses exceeding individual responses at magnitudes comparable to GHRH-GHRP-6 and GHRH-GHRP-2 synergy , confirming that Ipamorelins selective GHS-R1a pharmacology preserves the synergistic GH axis interaction with GHRH through complementary Gq/11 and Gs signalling mechanisms

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