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While direct human trials on the combination for cognition are sparse, the mechanistic synergy supports potential for addressing mitochondrial dysfunction in age-related cognitive decline [5]

In another model of diabetic neuropathy in rats, significant improvements in pain, oxidative stress, and inflammatory markers of the sciatic nerve were demonstrated following oral administration of amitriptyline and subcutaneous liraglutide, as well as with concurrent oral administration of amitriptyline and liraglutide loaded into proniosomal formulations [49]

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