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It says those patients should not pursue the change without specialized medical evaluation and a documented contraindication review

A bad diet - in a study feeding mice a western-style diet, impaired hepatic glutathione synthesis and lower plasma levels were found

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Low-Dose Naltrexone (Off-Label Use) How it works: Though not FDA-approved for weight loss, some healthcare providers use low-dose naltrexone off-label for appetite regulation and inflammation control

Therefore, caution is advised when taking any oral medications with Wegovy or Trulicity