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Distribution and uptake studies revealed distinct internalization of Cy5-labelled MPH NPs by LPS-stimulated RAW 264.7 cells (CD44-expressing) (Vachon et al., 2006) compared to NIH 3T3 (non-CD44-expressing) (Rios de la Rosa et al., 2017) cells, suggesting specific binding affinity of MPH NPs to CD44-positive cells ( Figure 6D )

This is not the first time the pharmaceutical company has come under scrutiny for quality lapses

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Patients should never attempt to "make up" for missed doses by taking extra medication or doubling doses