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The primary pathway involves activation of GLP-1 receptors located in the myenteric plexus of the enteric nervous system, coupled to Gs protein subunits that activate adenylyl cyclase and increase cyclic adenosine monophosphate (cAMP) levels [14]

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Novel anti- Wolbachia drugs here refers to drugs, which have either been specifically designed to target Wolbachia or new repurposed drugs that are active against Wolbachia