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In contrast, expression levels of FSH and LH released by the pituitary gland rise significantly to compensate for this loss, causing damage to normal ovarian tissue and germ cells and increasing the likelihood of developing POI in the ovary
The effect was dose-dependent and distinct from PDE5 inhibitors because it works centrally, through hypothalamic MC4R activation rather than peripheral vasodilation (Hadley, 2005)
It is not typically fatal
If pancreatitis is diagnosed, valproic acid should ordinarily be discontinued
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