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Moreover, in vitro studies of human and rat adipose tissue and isolated adipocytes revealed stimulatory effects of hCS on lipolysis.136, 137, 138 hCS also has been shown to increase theophylline-stimulated lipolysis, suggesting that the hormone enhances adipocyte sensitivity to other lipolytic agents.138 The effects of hCS extend to increased glucose uptake by adipocytes and oxidation and incorporation of glucose carbon into fatty acids and glycerol.139, 140 These actions are insulin-like, and subsequent studies have indicated that hCS augments adipose sensitivity to insulin in rat models

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Katsaros I, Sotiropoulou M, Vailas M, Kapetanakis EI, Valsami G, Tsaroucha A, et al

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Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease