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Both preclinical and clinical studies were included if they evaluated the effects of GLP-1 RAs on the major biological processes encompassed by the 12 hallmarks of aging, such as mitochondrial dysfunction, insulin resistance, dysbiosis, inflammaging, autophagy, proteostasis, and genomic stability
ISSN 0261-3077
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As the animals became more familiar with the task, they were able to find the platform more quickly, highlighting their spatial memory and learning abilities
Mounjaro (tirzepatide), on the other hand, acts on both the GLP1 and GIP (glucose-dependent insulinotropic polypeptide) receptors
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