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In a recent in vivo study utilizing an aging mouse model of IBD, chronic colitis triggered spatial and memory deficits (He et al., 2021)

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Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig

Toxicol Lett 185(3):211218