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Programme data have reported, for example, higher mean weight loss at 72 weeks with a GIP/GLP-1 regimen than with some GLP-1-only arms at different time pointscontext, population, and rescue/adherence rules all matter

Recent investigations have shifted predominantly toward topical delivery systems, reflecting ongoing challenges with oral curcumin bioavailability despite enhancement strategies

Gastrointestinal side effects are typically mild to moderate and occur most frequently during dose escalation

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