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For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids

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O'Connor PJ, Sperl-Hillen JM

Correspondingly, the protective effects of antioxidant supplementation have been observed in experimental models of NAFLD 15,16,17,18

In advanced CKD, potassium accumulates in the blood, which can lead to dangerous arrhythmias and other serious health problems