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From a population health perspective, the reported number needed to treat of approximately 65 to prevent one composite major adverse cardiovascular event highlights the clinical relevance of these therapies when applied at scale

CS10 / CagriSema is studied in the context of obesity (the REDEFINE 1 program) and type 2 diabetes (REDEFINE 2)

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187 A study also shows that purpurin and its analog, R162, acting as mixed model inhibitors of GDH1, inhibit GDH1 activity, elevate ROS levels and thus attenuate cancer cell proliferation

Conclusion Beyond their established role as potent antihyperglycemic agents, GLP-1RAs show potential for treating neurodegenerative diseases with disease-modifying effects