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Accumulated mtDNA fragments have been shown to activate the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway in chondrocyte models, promoting the expression of senescence-related markers such as p16INK4a and p21Cip1/Waf1, and inducing a senescent phenotype (60)

JAMA 1973

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In humans, HA supplementation by mouth was confirmed to be safe at dosages of up to 200 milligrams (mg) per day ingested for periods of up to 12 months