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C9orf72 mRNA sequesters a nucleocytoplasmic transport regulator in the cytoplasm, altering transport multiple RNAs and proteins through the nuclear pore [310]
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It is triggered by the small-molecule compound JTC801, which selectively induces intracellular lethal alkalinization without altering extracellular pH, and is characterized by disruption of lysosomal pH homeostasis [62, 63]
Chem Phys Lipids 157:111 Devasagayam T, Boloor K, Ramasarma T (2003) Methods for estimating lipid peroxidation: an analysis of merits and demerits
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