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Cuproptosis is based on the direct binding of copper ions to lipoylase proteins in the tricarboxylic acid cycle, leading to abnormal aggregation (174)
The C16orf87-HDAC1 interface (matching PICKLUSTER cluster 2) had a piCS score of 0.94, the C16orf87-MIER1 interface (matching the alpha-helix dock) had a piCS score of 0.89, and the HDAC1-MIER1 interface (matching the MIER1 ELM2-SANT/HDAC1 fold) had a piCS score of 0.95
PMCID: PMC11110809
Collagen and Elastin Synthesis: Supports the structural integrity of skin and hair, improving strength and resilience
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