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These associations involve chronic endogenous elevation, but they establish the biological plausibility of concern for long-acting exogenous analogues [8]

One concern for many regenerative treatments is that they could feed cancers if they are present

Compared to either subcomponent alone, the hydrogel/ADSC-EV complex enhances healing efficacy by promoting skin wound healing and re-epithelialization, stimulating collagen production, and elevating the expression of Ki67, -smooth muscle actin (-SMA), CD31, and skin barrier proteins while suppressing the expression of inflammatory factors [147]