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2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

GIP (glucose-dependent insulinotropic polypeptide) is another incretin hormone that, when targeted alongside GLP-1, complements the known benefits of GLP-1 receptor agonists, resulting in greater effects on blood glucose and body weight

Reconstitution means adding bacteriostatic water (BAC water) to freeze-dried (lyophilized) peptide powder to make an injectable solution

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Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]