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Mice were anesthetized by inhaling a mixture of 1 L/min oxygen and 1%1.5% isoflurane via a mask, while maintaining normal respiration

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In clinical trials, the half-life of cagrilintide (0.164.5 mg) ranged from 159 to 195 hours, and the elimination half-life ranged from 7 to 8 days, making cagrilintide suitable for once-weekly dosing