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Some conditions that require precaution include: Diabetic Retinopathy: In clinical trials, it was observed that brand-name semaglutide can temporarily worsen eye problems in diabetic patients due to sudden hypoglycemia (drops in blood glucose levels), which can worsen diabetic retinopathy

We further outline major technical constraints and unresolved mechanistic issues and highlight emerging approaches such as cell type resolved epigenomic mapping and locus specific epigenome editing that may enable more causal and translational insights

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Dang, L