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At the same time, as Fierce Pharma has noted, the rise of compounded alternatives and evolving IP dynamics has introduced parallel supply channels that are reshaping market share, pricing and forecasting for branded GLP-1 portfolios, including Ozempic and Wegovy

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Risks include hypoglycemia, insulin resistance, fluid retention, and potential mitogenic effects , especially with long-term use

Genomic analyses have revealed specific somatic mutations at codon 132 of the IDH1 gene in a higher proportion of secondary GBMs (85%) as compared to primary lesions (5%) (24)

Participants Twenty-five patients consented to be contacted by a member of the research team, of which 13 consented to take part in the study prior to initiation of the GLP-1 receptor agonist and completed baseline questionnaires