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Hypothyroidism, even in its subclinical form, is associated with: Higher fasting insulin Increased HOMA-IR (a measure of insulin resistance) Elevated fasting glucose and hemoglobin A1C in some cases While GLP-1s can improve glycemic control, their effectiveness may be reduced in the presence of uncontrolled thyroid disease

J., Cho, H., & Jeon, H

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Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors