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This study used targeted genetic models to pinpoint the mechanisms of Akkermansia in mice genetically engineered to lack intestinal FFAR4 which is known to regulate metabolism, lipogenesis, and gluconeogenesis

Furthermore, the data source used in this study encapsulated multiple hospital and physician networks, pharmacies, and health insurance companies, thereby increasing the relevance of the findings to patients seen in routine clinical practice

Xia T, Duan W, Zhang Z, Li S, Zhao Y, Geng B, Zheng Y, Yu J, Wang M (2021) Polyphenol-rich vinegar extract regulates intestinal microbiota and immunity and prevents alcohol-induced inflammation in mice

[6] In summary, aside from hypersensitivity, the use of pyridoxine should be guided by clinical necessity, and caution exercised in populations vulnerable to potential risks of excipients or overdose