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doi: 10.1007/s42000-019-00144-2 70 ChatchomchuanWThewjitcharoenYKarndumriKPorramatikulSKrittiyawongSWanothayarojEet al

With persistent hypoxia, HIF-1 remains activated and drives abnormal expression of downstream genes, including heme oxygenase-1 ( H O -1 ) (Zhai et al., 2023)