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Indeed, GSH is reported to be produced in the liver at levels higher than any other tissue in the body 29
Genetic studies reinforce this connection: mutations in ferroptosis-associated genes, such as DJ-1 (a negative regulator of ferroptosis linked to autosomal recessive PD) and ACSL4, have been implicated in PD susceptibility [132]
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That said, human safety data currently consists of only three small studies with no randomized controlled trials, and the longest follow-up spans just 6 to 12 months