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It belongs to a novel class of medications that activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, making it the first dual incretin receptor agonist available in clinical practice
as an add-on to metformin, sulfonylureas, and/or sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors) (SURPASS-2, -3, and -4)
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Other serious issues may be gallbladder problems and serious hypersensitivity reactions, like anaphylaxis
Also, sulfates, synthetic fragrances, and essential oils can cause irritation in sensitive skin
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