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**Other Indications:** May be used as part of a treatment regimen for certain metabolic disorders or conditions that require vitamin B12 supplementation

The ADA/EASD consensus report 4 highlights the use of DDP-4 inhibitors when intermediate efficacy for glucose lowering is required and where weight management goals would prefer a weight-neutral approach

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To assess the binding the cofactors, 1mM FeDPP or heme were dissovled in DMSO and mixed with proteins in PBS buffer (137 mM NaCl, 2.7 mM KCl, 10 mM Na 2 HPO 4, 1.8 mM KH 2 PO 4, pH 7.4) for a final cofactor concentration of 5 M, and increasing concentration of protein (0.05, 0.1, 0.25, 0.5, 0.75, 1.0, 2.0, and 5.0 equivalent of cofactor) to a total volume of 200 L