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Herpes simplex virus type 1 and Alzheimers disease: increasing evidence for a major role of the virus

[10] Synergy is observed when tretinoins barrier-disruptive effect is offset by niacinamide-induced ceramide synthesis, allowing maintenance of retinoid efficacy with fewer erythema and peeling events

They also promote the release of inflammatory cytokines including interleukin 1 (IL-1), and tumor necrosis factor (TNF a) which act within the irradiated tissue as well as enter systemic circulation experiences cell killings (Brown and Wilson 2004

Patch testing before first use is recommended

So, I mean, all of these things, cradle cap, reflux, colic, are all signs of a immune and gastrointestinal immune disruption