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Proc Natl Acad Sci USA 104 : 1662116626

This repeated warming and cooling stresses peptide stability more than consistent cold storage

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Sensory signals control the release of hypothalamic corticotropin-releasing hormone (CRH) and vasopressin (AVP) from the paraventricular nucleus and into the pituitary portal circulation, where they reach the adenohypophysis and stimulate the release of adrenocorticotropic hormone (ACTH), which in turn promotes adrenocortical production and cortisol release (74)