There are some data that acute COVID-19 infection is accompanied by signs of oxidative stress, including increased expression of ROS-response genes and glycolysis in peripheral blood mononuclear cells [72], increased MDA (TBARS assay), F-isoprostane, 8-hydroxy-2-deoxyguanosine, AOPP and nitrotyrosine levels, and lowered glutathione (GSH), -SH groups, selenium, zinc, TAC and vitamin D [49, 73,74,75,76,77,78,79]
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In addition, transcription factorsincluding Fos , Junb and Egr1 were also upregulated, which is consistent with our transcriptomic analysis of Caco-2 cells treated with clofazimine (Extended Data Fig
Moreover, BPC 157 has been shown to upregulate growth factors like VEGF (vascular endothelial growth factor) that is essential for cellular regeneration and repair