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Link Novel tricyclic small-molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders

Nature Chemical Biology

(2) Balancing Fat Metabolism and Promoting Lipolysis and Energy Expenditure In obesity, the metabolic balance of adipose tissue is disrupted, characterized by enhanced lipogenesis and weakened lipolysis, leading to continuous fat accumulation

Studies have shown that the product treatment increases grip strength by approximately 40% in aged mice, and combined with exercise, further improves muscle regenerative capacity and metabolic function

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