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Based on clinical trials and FDA labeling, gastrointestinal side effects, including diarrhea, commonly occur early in treatment and with dose increases, then tend to lessen after dose stabilization
As all people with diabetes are at high risk of CVD, HF and CKD over time, real-world evidence and cost-effectiveness studies of GLP-1 RA and SGLT2i in broad populations would help to better target interventions to have the greatest impact on outcomes
HARMONY 4: randomised clinical trial comparing once-weekly albiglutide and insulin glargine in patients with type 2 diabetes inadequately controlled with metformin with or without sulfonylurea
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