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doi: 10.1038/nm.3806 26 CostaT.J.PotjeS.R.Fraga-SilvaT.F.C.da Silva-NetoJ.A.BarrosP.R.RodriguesD.et al (2022)

This study was conducted in compliance with the principles set forth in the Declaration of Helsinki

It is the primary anabolic hormone in the body, facilitating glucose uptake into muscle, fat, and liver cells while inhibiting glucose production by the liver

These findings support the use of retatrutide in laboratory studies examining how coordinated GLP-1R, GIPR, and GCGR activation affects hepatic metabolic regulation [5][8]