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Furthermore, a greater proportion of patients achieved HbA 1c reduction 1% with body weight loss 3% at Week 26 with oral semaglutide 7 and 14 mg than with placebo and active comparators [38, 39, 61, 62, 76, 77, 81, 82]
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There are several plausible explanations for this experience, and it is important to approach them methodically rather than assuming the medication is not working
The safety profile of combining tirzepatide and metformin is generally favorable, though patients should be aware of both medication-specific adverse effects and potential considerations when using them together
