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No reliable human safety profile has been established through controlled clinical development
Because its relatively safe, However, vitamin B12 has been shown to cause rare side effects in some cases
Before treatment, establish selenium status of stock and pasture cobalt levels and/or Vitamin B12 status of stock
These include how the patient is doing, any health problems, and the testing method
A 2022 study in Diabetes, Obesity and Metabolism showed that NNMTi treatment combined with reduced-calorie diet "promoted dramatic whole-body adiposity and weight loss in diet-induced obese mice, rapidly normalizing" weight parameters
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